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US 11,298,371 B2Granted
Regulation of nucleic acid molecule expression
AssigneeNitto Denko Corporation
InventorsKenjiro Minomi, Naoko Urushihara, Yusuke Nakashima, Hiroyuki Tanaka, Erika Terada
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Abstract
The present invention provides a nucleic acid molecule dimer that includes a first nucleic acid molecule having complementarity with at least part of a target nucleic acid molecule, and a second nucleic acid molecule having complementarity with the first nucleic acid molecule, wherein the first nucleic acid molecule has a linear form, the second nucleic acid molecule has a cyclic form, and the first and second nucleic acid molecules at least partially form a double strand.
Claims16
A nucleic acid molecule dimer comprising:
- a first nucleic acid molecule of 15 to 30 mer having at least 80% complementarity to at least a portion of a target nucleic acid molecule;
- and
- a second nucleic acid molecule of 12 to 30 mer having at least 76% complementarity to the first nucleic acid molecule,
- wherein the first nucleic acid molecule is linear, the second nucleic acid molecule is circular, and the first nucleic acid molecule and the second nucleic acid molecule at least partially form a duplex.
1 more element
Dependencies are inferred from the claim text.