Ophthalmic compositions of brinzolamide
AssigneeShilpa Medicare Limited
InventorsSaraganachari Andanayya, Narayanaswamy Abhilash, Sreenivasa Reddy, Shivakumar Pradeep
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Abstract
The present invention relates to an aqueous ophthalmic solution for treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma, the solution comprising at least 0.5 w/v % brinzolamide dissolved in the solution; hydroxy-propyl-β-cyclodextrin; polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; and water and/or the process for preparation thereof.
Claims10
An aqueous ophthalmic solution for treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma, the solution comprising
- (a) at least 0.5 w/v % brinzolamide dissolved in the solution;
- (b) at least 1.0 w/v % but no greater than 10.0 w/v % hydroxy-propyl-β-cyclodextrin;
- (c) about 0.2 w/v % to about 5.0 w/v % polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer;
- and
- (d) water;
- wherein the pH of the solution is about 6.0 to about 7.8 and wherein the ophthalmic solution is free of polysorbate 80.
An aqueous ophthalmic solution comprising
- (a) at least 0.5 w/v % brinzolamide but no greater than 0.95 w/v % of brinzolamide dissolved in the solution;
- (b) at least 1.0 w/v % but no greater than 10.0 w/v % hydroxy-propyl-β-cyclodextrin;
- (c) about 0.2 w/v % to about 5.0 w/v % polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer;
- (d) about 0.1 w/v % to about 1.0 w/v % sodium chloride;
- and
- (e) water;
- wherein the pH of the solution is about 6.0 to about 7.8 and wherein the ophthalmic solution is free of polysorbate 80.
Dependencies are inferred from the claim text.