Inhalable imatinib formulations, manufacture, and uses thereof
AssigneeAerovate Therapeutics, Inc.
InventorsBen Dake, Ralph Niven, Andrew D. Levin
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Abstract
The invention relates to inhalable imatinib formulations, manufacture, and uses thereof.
Claims15
An inhalable formulation comprising micronized particles of imatinib freebase having a type A crystal structure, the micronized particles having a mass median aerodynamic diameter in the range of about 0.5 μm to about 5 μm and the inhalable formulation comprising less than 5% amorphous imatinib particles and less than 5% water, wherein imatinib freebase is the only active pharmaceutical ingredient in the inhalable formulation.
A method of treating pulmonary arterial hypertension (PAH), the method comprising providing to a subject an inhalable formulation comprising micronized particles of imatinib freebase having a type A crystal structure, the micronized particles having a mass median aerodynamic diameter in the range of about 0.5 μm to about 5 μm and the inhalable formulation comprising less than 5% amorphous imatinib particles and less than 5% water, wherein imatinib freebase is the only active pharmaceutical ingredient in the inhalable formulation.
Dependencies are inferred from the claim text.