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US 11,298,347 B2Granted
Methods of diagnosing and treating Tourette syndrome
AssigneeThe Children's Hospital of Philadelphia
InventorsHakon Hakonarson, Charlly Kao
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Abstract
Methods and uses for diagnosing and treating Tourette syndrome are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
Claims19
A method for treating Tourette syndrome (TS) in a subject comprising
- (a) isolating a sample comprising nucleic acid from a subject that has TS,
- (b) detecting at least one CNV in a mGluR network gene of the subject,
- (c) administering an effective amount of fasoracetam to the subject with the at least one CNV in a mGluR network gene, and
- (d) assessing the subject for a reduction in tic symptoms following at least 4 weeks of treatment with fasoracetam.
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Dependencies are inferred from the claim text.