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US 11,298,341 B2Granted
PSMA binding ligand-linker conjugates and methods for using
AssigneePurdue Research Foundation
InventorsPhilip S. Low, Sumith A. Kularatne
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Abstract
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
Claims11
A compound of the formula:
- B-L-IA
- or a pharmaceutically acceptable salt thereof, wherein:
- B is of the formula
- wherein * represents the point of attachment to L;
- L is a divalent linker of at least 14 atoms in length, the divalent linker comprising one or more of a divalent cycloalkyl, cycloalkane diradical, cycloalkylene, alkylenecycloalkyl, cycloalkylenecarbonyl, heterocyclyl, aryl, arylalkylene, heteroaryl, a divalent amino alkylene carbonyl group, arylene, or cyclo-imide group and at least one group:
- —N(H)—(CR′R″)q—C(O)—
- wherein q is 1, R′ is hydrogen, and R″ is the side chain of glutamic acid;
- and L does not comprise an arylalkyl side chain;
- and
- IA is an optical imaging agent selected from the group consisting of fluorescein, BODIPY F1, BODIPY 505, tetramethylrhodamine, ALEXA FLUOR™ 488, ALEXA FLUOR™ 647, DYLIGHT™ 680, DYLIGHT™ 800, IR800CW, indocyanine green, OREGON GREEN™ 488, OREGON GREEN™ 514, Texas Red, and phycoerythrin.
7 more elements
Dependencies are inferred from the claim text.