Parthenolide and its derivative for use in the treatment of axonal damage
AssigneeRuhr-UniversitäT Bochum
InventorsPhilipp Ludwig Alexander Gobrecht, Dietmar Fischer
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Abstract
The present invention relates to a compound reducing microtubule detyrosination in axonal tips selected from the group consisting of tubulin carboxypeptidase inhibitors and tubulin tyrosine ligase activators and combinations thereof for use in the treatment of axonal damage.
Claims2
A method of regenerating axonal damage, wherein the axonal damage is an injury of the sciatic nerve, the method comprising administering to a subject a therapeutically effective amount of a compound reducing microtubule detyrosination in axonal tips selected from cnicin or a pharmaceutically acceptable salt thereof.
A method of regenerating axonal damage, wherein the axonal damage is an axotomy of the sciatic nerve, the method comprising administering to a subject a therapeutically effective amount of a compound reducing microtubule detyrosination in axonal tips selected from cnicin or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.