Solid pharmaceutical preparation containing levothyroxine
AssigneeMerck Patent GmbH
InventorsHiltrud Lindenblatt, Thomas T. Frank, Reiner Vonderschmitt
Life of this patent
Estimating the term…
Abstract
The invention relates to a solid pharmaceutical preparation comprising levothyroxine sodium, gelatine, citric acid and a filler. The solid pharmaceutical preparation has an improved stability.
Claims18
A solid pharmaceutical preparation comprising levothyroxine sodium, 2-10% by weight based on the preparation of gelatine, 0.2 to 3% by weight based on the preparation of citric acid, and a filler that is 50 to 80% by weight, based on the preparation, of mannitol, sucrose or lactose, and 10 to 30% by weight, based on the preparation, of maize starch.
A process for the stabilization of levothyroxine sodium, comprising adding to a composition of said levothyroxine sodium a stabilizing-effective amount of gelatine, citric acid and a filler that is sucrose, mannitol or lactose and maize starch, whereby said composition contains, by weight, based on the composition, 2-10% gelatine, 0.2-3% citric acid, 50-80% mannitol, sucrose or lactose and 10 to 30% maize starch.
Dependencies are inferred from the claim text.