Sensorineural hair cell differentiation
AssigneeMassachusetts Eye and Ear Infirmary
InventorsAlbert Edge, Judith Kempfle, Dunia Abdul-Aziz
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Abstract
The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss. Such compositions and methods include modulating the epigenetic status of the cell, or rate of protein degradation, to increase expression and/or levels of Atoh1 protein.
Claims7
A method for treating sensorineural hearing loss associated with loss of auditory hair cells in a subject, the method comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a histone methyltransferase (HMT) inhibitor to the subject having sensorineural hearing loss, wherein the therapeutically effective amount is an amount sufficient to improve hearing at one or more frequencies.
Dependencies are inferred from the claim text.