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US 11,298,327 B2Granted
Methods and compositions for treating and preventing arthritis
AssigneeAlbert Einstein College of Medicine
InventorsHui B. Sun, Daniel J. Leong, Neil J. Cobelli, David M. Hirsh, John A. Hardin, Karen E. Sperling, Sun J. Kim, David C. Spray, Chandan Guha, Marwa Choudhury
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Abstract
Methods and formulations are provided for treating or preventing arthritis, in particular osteoarthritis, where the formulation to be administered to a subject for treating or preventing arthritis comprises carvacrol, curcumin, epigallocatechin-3-gallate and oligomeric procyanidins.
Claims16
A method of treating osteoarthritis in a subject in need thereof, comprising administering to the subject as active agents:
- a therapeutically-effective amount of carvacrol;
- a therapeutically-effective amount of curcumin;
- a therapeutically-effective amount of epigallocatechin-3-gallate;
- and
- a therapeutically-effective amount of oligomeric procyanidins,
- wherein the therapeutically-effective amounts of carvacrol, curcumin, epigallocatechin-3-gallate, and oligomeric procyanidins are selected to synergistically increase expression of Cbp/p300 interacting transactivator with ED-rich tail 2 (CITED2) in the subject, and
- wherein the carvacrol, the curcumin, the epigallocatechin-3-gallate, and the oligomeric procyanidins are present in a molar ratio of 1:1:100:50 or in a weight ratio of 10:10:1:10.
4 more elements
Dependencies are inferred from the claim text.