Methods for treating metabolic disorder

A method of treating a metabolic disorder or disease in a subject in need thereof, comprising

• administering to the subject a therapeutically effective amount of a 3D-printed tablet, wherein the 3D-printed tablet comprises glimepiride (GLMP) and rosuvastatin (RSV) or pharmaceutically acceptable salts thereof, and 10-20 wt. % of curcuma oil in a self-nanoemulsifying drug delivery system (SNEDDS),
• wherein the 3D-printed tablet is a multi-compartmentalized tablet having at least one layer of GLMP and at least one layer of RSV in separate compartments, wherein each compartment is configured to release GLMP or RSV at a different rate,
• wherein the GLMP and rosuvastatin RSV are at a weight ratio of about 3:1 to 1:3, and
• wherein the metabolic disorder or disease is selected from the group consisting of diabetes, hyperlipidemia, and liver disease.