Methods of treatment of cancer by continuous infusion of coenzyme Q10
AssigneeBerg LLC
InventorsNiven Rajin Narain, Rangaprasad Sarangarajan, Thomas Mitchell Gray, John Patrick McCook, Joaquin J. Jimenez
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Abstract
The invention provides regimens and methods for the treatment of cancer comprising continuous infusion of coenzyme Q10. The coenzyme Q10 may be administered as a monotherapy, or in combination with an additional agent, such as an anticancer agent, a chemotherapeutic agent, or an anti-angiogenic agent. The coenzyme Q10 may be administered at two or more different rates.
Claims36
A method of treating cancer in a subject, comprising administering a composition comprising from 0.001% to 20% (w/w) of coenzyme Q10 by continuous intravenous infusion for at least 48 hours, thereby treating the cancer in the subject.
A method of preventing or limiting severity of an adverse event associated with treatment of cancer with intravenously administered coenzyme Q10, comprising administering to a subject having cancer a composition comprising from 0.001% to 20% (w/w) of coenzyme Q10 by continuous intravenous infusion for at least 48 hours, wherein the severity of the adverse event in the subject is reduced as compared to intravenous administration of the same dose of coenzyme Q10 over a period of 6 hours or less.
Dependencies are inferred from the claim text.