System having anchored interface for shaping and positioning a tissue body

A device for use in a tissue interface of a tissue positioning system coupled to an ultrasound imaging apparatus, the device comprising:

• an interface pad configured to replaceably attach to an upper surface of an interface plate of the tissue positioning system by an attachment mechanism, wherein the interface pad has a center aperture which fluidly couples to a low pressure source of the tissue positioning system via at least one perforation in a center region of the interface plate when the interface pad is replaceably attached to the upper surface of the interface plate and the interface plate is mounted on a support column of the tissue positioning system,
• wherein the attachment mechanism is free from a peripheral rim to reduce image artifact from the attachment mechanism, wherein the interface pad is configured to receive a tissue volume without obstructing ultrasound energy directed radially through the interface pad from the ultrasound imaging apparatus coupled to the tissue positioning system, and wherein a vacuum circuit is configured to be closed or completed when the tissue volume makes contact and seals the center aperture of the interface pad.