Methods for biomedical targeting and delivery and devices and systems for practicing the same

A method of magnetic resonance imaging (MRI)-assisted delivery of an agent or an electrical current to a desired area of a subject, the method comprising:

• positioning a base comprising a plurality of annular walls forming a socket on a tissue surface of a subject;
• positioning an adjustable turret comprising a channel and a spherical end into the base, wherein the socket is dimensioned to receive the spherical end and allow the turret to undergo an adjustment comprising an angle adjustment and a roll adjustment;
• inserting a MRI-visible stylet of a trajectory guide within the channel of the adjustable turret;
• visualizing the MRI-visible stylet using an MRI imager;
• determining the trajectory of the channel based on the visualizing;
• and
• adjusting the adjustable turret based on the determined trajectory of the channel to target the desired area of the subject;
• removing the MRI-visible stylet from the channel following the adjusting;
• and
• delivering the agent or the electrical current through the channel to the desired area of the subject.