Methods for biomedical targeting and delivery and devices and systems for practicing the same

An adjustable targeting system, the system comprising:

• an adjustable turret comprising a distal end, a spherical end and one or more channels running from the distal end to the spherical end;
• an angular base, comprising:
• a plurality of annular walls in a non-orthogonal relationship with a bottom surface of the angular base forming a socket dimensioned to receive the spherical end;
• threading on an external surface of the annular walls;
• a plurality of slots positioned between the plurality of annular walls;
• and
• at least one flange for affixing the angular base to a tissue surface of a subject;
• a locking collar comprising threading on an internal surface compatible with the threading on the external surface of the angular base, wherein the locking collar locks the adjustable turret in a desired trajectory and releasing the locking collar allows for retargeting of the trajectory of the adjustable turret;
• and
• a trajectory guide, comprising:
• a solid support comprising a flat surface;
• a magnetic resonance imaging (MRI)-visible style comprising a lumen comprising a contrast agent, wherein the MRI-visible style is affixed at one end to the flat surface and dimensioned for insertion into a channel of the one or more channels of the adjustable turret thereby allowing targeting of the channel by visualizing the trajectory of the inserted MRI-visible style;
• and
• a second MRI-visible style comprising a lumen comprising a contrast agent, wherein the second MRI-visible style is affixed at one end to the flat surface and dimensioned for insertion into a channel of the one or more channels of the adjustable turret.