Biologically applicable water-soluble heterogeneous catalysts for para-hydrogen induced polarization
AssigneesThe Regents of the University of California, Cedars-Sinai Medical Center
InventorsLouis Bouchard, Shawn Wagner, Stefan Gloeggler
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Abstract
A heterogeneous catalyst composition for para-hydrogen induced polarization includes ligand-capped nanoparticles dispersed in water. The ligand-capped nanoparticles include metal nanoparticles that are surface functionalized with organic ligands, a molecular weight of the organic ligands is no greater than 300 g/mol, and the organic ligands each includes multiple binding moieties as coordinates sites for binding to a nanoparticle surface.
Claims17
A heterogeneous catalyst composition for para-hydrogen induced polarization, comprising ligand-capped nanoparticles dispersed in water,
- wherein the ligand-capped nanoparticles include metal nanoparticles consisting of a platinum group metal that are surface functionalized with an organic ligand, a molecular weight of the organic ligands is no greater than 250 g/mol, and the organic ligands each includes multiple binding moieties as coordination sites for binding to a nanoparticle surface,
- wherein the organic ligands each includes a sulfhydryl group and an amino group as the binding moieties, and further includes at least one hydrophilic moiety,
- wherein the platinum group metal is rhodium.
A method for synthesis of ligand-capped nanoparticles, comprising:
- combining a platinum group metal-containing precursor and organic ligands in a solvent;
- and
- reducing the platinum group metal-containing precursor in the presence of a reducing agent, thereby forming the ligand-capped nanoparticles,
- wherein the ligand-capped nanoparticles include metal nanoparticles consisting of a platinum group metal that are surface functionalized with the organic ligand,
- wherein a molecular weight of the organic ligands is no greater than 250 g/mol, and the organic ligands each includes multiple binding moieties as coordination sites for binding to a nanoparticle surface,
- wherein the organic ligands each includes a sulfhydryl group and an amino group as the binding moieties, and further includes at least one hydrophilic moiety,
- wherein the platinum group metal is selected from the group consisting of rhodium.
Dependencies are inferred from the claim text.