Zika virus vaccine
AssigneePresident and Fellows of Harvard College
InventorsSean P. J. Whelan, Sayantan Bose, Joseph Timpona
Life of this patent
Estimating the term…
Abstract
Compositions and methods useful for treating and/or preventing a Zika virus infection are provided.
Claims6
A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, wherein the nucleic acid encoding the Zika virus E protein has a sequence that is at least 90% identical to SEQ ID NO:2.
A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, further comprising in its genome a nucleic acid sequence encoding a Zika virus precursor membrane (prM) protein or fragment thereof, wherein the nucleic acid encoding Zika virus prM has a sequence that is at least 90% identical to SEQ ID NO:
- 3.
A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, further comprising in its genome a nucleic acid sequence encoding a Zika virus precursor membrane (prM) protein or fragment thereof and a nucleic acid sequence encoding Zika virus capsid (C) protein or fragment thereof, wherein the nucleic acid encoding Zika virus capsid (C) protein has a sequence that is at least 90% identical to SEQ ID NO:4.
A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, wherein the genome of the recombinant VSV has a nucleic acid sequence that is at least 90% identical to SEQ ID NO:5.
A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, wherein the genome of the recombinant VSV has a nucleic acid sequence that is at least 90% identical to SEQ ID NO:6.
A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, wherein the genome of the recombinant VSV has a nucleic acid sequence that is at least 90% identical to SEQ ID NO:7.
Dependencies are inferred from the claim text.