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US 11,118,231 B2Granted
miRNAs as biomarkers for distinguishing benign from malignant thyroid neoplasms
AssigneeInterpace Diagnostics Corporation
InventorsSylvie Beaudenon-Huibregtse, Ashish Choudhary
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Abstract
The present invention concerns methods and compositions for identifying a miRNA profile for a particular condition, such as thyroid nodules or thyroid cancer, and using the profile in the diagnosis of a patient for a condition, such as thyroid nodules or thyroid cancer.
Claims6
A method of producing labeled nucleotide sequences from a thyroid sample from a subject, the method comprising
- contacting the thyroid sample from the subject with labeled primers specific for a group of microRNAs consisting of miR-375, miR-146b-5p, mir-138-1*, and miR-204;
- and
- reacting the sample with the labeled primers under conditions to amplify the microRNAs using polymerase chain reaction to produce the labeled nucleotide sequences.
Dependencies are inferred from the claim text.