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US 11,112,413 B2Granted
Multiplexed immunohistochemistry using recombinant antibodies with epitope tags
AssigneeVentana Medical Systems, Inc.
InventorsMichael Farrell, Antony Hubbard, Eric May, Lei Tang, Tsu-Shuen Tsao, Wenjun Zhang
Life of this patent
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Abstract
The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.
Claims7
A kit comprising:
- (a) at least one epitope-tagged antibody, wherein the at least one epitope-tagged antibody comprises an antibody and at least one epitope tag construct, and
- (b) detection reagents for detecting the at least one epitope-tagged antibody,
- wherein the detection reagents comprise at least one anti-tag antibody, wherein the at least one anti-tag antibody is specific for an expressed epitope tag of the at least one epitope-tagged antibody, and
- wherein the at least one epitope tag construct consists of the amino acid sequence selected from the group consisting of SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, and SEQ ID NO:32.
1 more element
Dependencies are inferred from the claim text.