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US 11,112,403 B2Granted
Assessment of preeclampsia using assays for free and dissociated placental growth factor
AssigneeProgenity, Inc.
InventorsPankaj Oberoi, Sharat Singh, Amin Mazloom
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Abstract
Described herein are methods, compositions, kits, and systems for detecting free and bound PlGF, and using detection of such species to distinguish between pregnant women with or without preeclampsia or related conditions.
Claims20
A method for determining levels of free and dissociated PlGF in a biological sample from a pregnant human female subject, the method comprising:
- (a) isolating a first aliquot of the biological sample for the detection of PlGF-f and a second aliquot of the biological sample for the detection of PlGF-d;
- (b) determining an amount of PlGF-f in the first aliquot;
- (c) applying a treatment to the second aliquot to dissociate PlGF complexes;
- and
- (d) determining an amount of PlGF-d in the second aliquot.
2 more elements
Dependencies are inferred from the claim text.