US 11,111,508 B2Granted

Modified CAS9 compositions and methods of use

AssigneeBrandeis University

InventorNelson Lau

Life of this patent

Estimating the term…

Abstract

The invention features Cas9 fusion polypeptides. In one embodiment of the invention, Cas9 is fused to a SNAP tag that enhances Cas9's gene repair function.

Claims7

Dependent claims

A Cas9 fusion polypeptide having the sequence of SEQ ID NO:2.

Dependencies are inferred from the claim text.

Facts

Application: 15/762,025Filed 25 Oct 2016 · us provisional application
Priority: 30 Oct 2015
Published: US 2018/0265895 A120 Sep 2018
Granted: 7 Sep 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

C12N 9/22
Acting on ester bonds: ribonucleases [RNase]; Deoxyribonucleases [DNase]
C12N 15/907
Using homologous recombination: in mammalian cells
C12N 9/226
Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes: class 2 CAS enzyme complex, e.g. single CAS protein
C12N 15/11
Recombinant DNA-technology: dNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity

Family

Application62/249,113Us provisional application · filed 30 Oct 2015
US 2018/0265895 A1Pre-grant publication · published 20 Sep 2018
US 11,111,508 B2This patent

From the US filing history. Foreign family members aren’t listed.

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