Chitosan-derived compositions
AssigneeImmunophotonics, Inc.
InventorsTomas Hode, Robert Nordquist, Wei R. Chen, Raoul Carubelli, Luciano Alleruzzo, Peter Jenkins, Kristopher Waynant, Joseph Raker
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Abstract
The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.
Claims19
A pharmaceutical formulation comprising a glycated chitosan having a molecular weight of about 100,000 to about 300,000 Daltons;
- wherein the glycated chitosan has a degree of deacetylation of about 75% to about 99% and a degree of glycation of free amino groups of about 0.1% to about 30%;
- and further wherein the pharmaceutical formulation is a sterile aqueous solution formulated for injection, and further wherein either:
- the glycated chitosan has a molecular weight of about 250,000 Daltons;
- or
- the glycated chitosan has a degree of glycation of about 2-7% or about 12.5%.
A method of generating an in situ autologous vaccine, comprising:
- ablating a neoplasm in a host, thereby releasing fragmented neoplastic tissue and cellular molecules;
- and introducing a pharmaceutical formulation comprising a glycated chitosan into the neoplasm, wherein:
- the glycated chitosan has a molecular weight of about 100,000 to about 300,000 Daltons;
- the glycated chitosan has a degree of deacetylation of about 75% to about 99%;
- and
- the glycated chitosan has a degree of glycation of free amino groups of about 0.1% to about 30%.
A method of enhancing immune system response to an antigen in a patient in need thereof, comprising administering a pharmaceutical formulation comprising a glycated chitosan into the neoplasm, wherein:
- the glycated chitosan has a molecular weight of about 100,000 to about 300,000 Daltons;
- the glycated chitosan has a degree of deacetylation of about 75% to about 99%;
- and
- the glycated chitosan has a degree of glycation of free amino groups of about 0.1% to about 30%.
Dependencies are inferred from the claim text.