Anti-DLL3 antibody
AssigneesChugai Seiyaku Kabushiki Kaisha, The University of Tokyo
InventorsKenji Yoshida, Hiroyuki Aburatani, Shumpei Ishikawa
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Abstract
It is intended to disclose an antibody which binds to DLL3 protein. Preferably, the antibody of the present invention recognizes a region from amino acids 216 to 492 in human DLL3 having the amino acid sequence as set forth in SEQ ID NO: 1. The present invention also provides a pharmaceutical composition, for example, an anticancer agent, comprising the antibody of the present invention as an active ingredient. The present invention further discloses a method for diagnosing cancer using the antibody of the present invention and a diagnostic drug for cancer comprising the antibody of the present invention.
Claims17
An antibody that binds to DLL3 having the amino acid sequence of SEQ ID NO:
- 1, wherein said antibody binds to a region between amino acids 216 to 492 of SEQ ID NO:
- 1, wherein the antibody has an internalizing activity and is either conjugated to, or is capable of being conjugated to, one or more cytotoxic substances,
- and wherein the anti-DLL3 antibody is
- an antibody comprising a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence as set forth in SEQ ID NO:
- 36, heavy chain CDR2 having the amino acid sequence as set forth in SEQ ID NO:
- 37, and heavy chain CDR3 having the amino acid sequence as set forth in SEQ ID NO:
- 38, and a light chain variable region comprising light chain CDR1 having the amino acid sequence as set forth in SEQ ID NO:
- 42, light chain CDR2 having the amino acid sequence as set forth in SEQ ID NO:
- 43, and light chain CDR3 having the amino acid sequence as set forth in SEQ ID NO:
- 44.
A method of identifying or selecting an anti-DLL3 antibody having internalizing activity that can bind to a region between amino acids 216 to 492 of SEQ ID NO:
- 1,
- wherein said method comprises identifying or selecting, from a plurality of antibodies, an antibody which binds to a region between amino acids 216 to 492 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.