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US 11,111,308 B2Granted
Anti-human transferrin receptor antibody capable of penetrating blood-brain barrier
AssigneeJCR Pharmaceuticals Co., Ltd.
InventorsHiroyuki Sonoda, Kenichi Takahashi
Life of this patent
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Abstract
Provided is an anti-human transferrin receptor antibody or an analog thereof, wherein in the heavy chain variable region of the antibody, (a) CDR1 comprises the amino acid sequence set forth as SEQ ID NO: 62 or SEQ ID NO: 63, (b) CDR2 comprises the amino acid sequence set forth as SEQ ID NO: 13 or SEQ ID NO: 14, and (c) CDR3 comprises the amino acid sequence set forth as SEQ ID NO: 15 or SEQ ID NO: 16, and an analogue thereof.
Claims47
An anti-human transferrin receptor antibody, wherein the heavy chain variable region of the antibody comprises,
- (a) CDR1 comprising the amino acid sequence of SEQ ID NO:
- 62 or SEQ ID NO:
- 63,
- (b) CDR2 comprising the amino acid sequence of SEQ ID NO:
- 13 or SEQ ID NO:
- 14, and
- (c) CDR3 comprising the amino acid sequence of SEQ ID NO:
- 15 or SEQ ID NO:
- 16, and the light chain variable region of the antibody comprises,
- (a) CDR1 comprising the amino acid sequence of SEQ ID NO:
- 6,
- (b) CDR2 comprising the amino acid sequence of SEQ ID NO:
- 8, and
- (c) CDR3 comprising the amino acid sequence of SEQ ID NO:
- 10.
12 more elements
Dependencies are inferred from the claim text.