Conjugates comprising a vascular endothelial growth factor (VEGF) antibody and a hyaluronic acid polymer
AssigneeGenetech, Inc.
InventorsAmin Famili, Germaine Fuh, Patrick Koenig, Chingwei Vivian Lee, Karthikan Rajagopal
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Abstract
The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).
Claims41
An antibody conjugate comprising (i) an antibody that specifically binds to vascular endothelial growth factor (VEGF) and (ii) a hyaluronic acid (HA) polymer covalently attached to the antibody, wherein the HA polymer has a polydispersity index (PDI) of between 1.0 and 1.1.
An antibody conjugate comprising (i) an antibody that specifically binds to VEGF and (ii) an HA polymer covalently attached to the antibody, wherein the HA polymer has a PDI of between 1.0 and 1.1, wherein the antibody comprises the following six hypervariable regions (HVRs):
- (a) an HVR—H1 comprising the amino acid sequence of SEQ ID NO:
- 1;
- (b) an HVR—H2 comprising the amino acid sequence of SEQ ID NO:
- 2;
- (c) an HVR—H3 comprising the amino acid sequence of SEQ ID NO:
- 3;
- (d) an HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 4;
- (e) an HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 5;
- and
- (f) an HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 6.
An antibody conjugate comprising (i) an antibody that specifically binds VEGF and (ii) an HA polymer covalently attached to the antibody, wherein the HA polymer has a PDI of 1.05, and wherein the antibody comprises (a) a VH domain comprising the amino acid sequence of SEQ ID NO:
- 11 and (b) a VL domain comprising the amino acid sequence of SEQ ID NO:
- 12.
An antibody conjugate comprising (i) an antibody that specifically binds VEGF and (ii) an HA polymer covalently attached to the antibody, wherein the HA polymer has a PDI of 1.05, and wherein the antibody comprises (a) a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 48 or SEQ ID NO:
- 49 and (b) a light chain comprising the amino acid sequence of SEQ ID NO:
- 50.
Dependencies are inferred from the claim text.