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US 11,111,285 B2Granted
Glucagon-GLP-1-GIP triple agonist compounds
AssigneeZealand Pharma A/S
InventorsRasmus Just, Ditte Riber, Anne Pernille Tofteng Shelton, Torben Østerlund, Kate Hansen, Lene Jessen
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Abstract
The present invention relates to compounds which have agonist activity at the glucagon, GIP and GLP-1 receptors, and to their use in the treatment of metabolic disorders.
Claims7
A glucagon-GLP-1-GIP triple agonist compound having the general formula:
- R1-Y-Aib-QGTFTSDYSIYLDK-K([17-carboxy-heptadecanoyl]-isoGlu)-AQRAFVEWLLAQGPSSGAPPPS-R2 (SEQ ID NO:
- 33)
- wherein
- R1 is H—, C1-4 alkyl, acetyl, formyl, benzoyl, trifluoroacetyl or pGlu;
- R2 is —NH2 or —OH;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.