Compositions and methods for vascular protection against reperfusion injury after myocardial ischemia
AssigneeThe University of Vermont and State Agriculture College
InventorJeffrey Spees
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Abstract
As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.
Claims6
A method for reducing vascular endothelial cell damage or vascular endothelial cell death following myocardial ischemia with reperfusion in a subject, the method comprising administering to the subject intra-arterially a composition comprising an HGF/IgG complex at the time of reperfusion, wherein the HGF/IgG complex does not comprise an antibody-antigen interaction, thereby reducing vascular endothelial cell damage or vascular endothelial cell death following myocardial ischemia with reperfusion relative to a reference.
Dependencies are inferred from the claim text.