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AssigneeGrand Valley State University
InventorsMerritt DeLano-Taylor, Jordan Straight, Doug Peterson, Nick Huisingh, Daniel Doyle
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The present invention relates to isolated Nato3 mutant polypeptides. Methods for stimulating a brain cell to differentiate into a dopaminergic progenitor neuronal cell or a dopaminergic neuron comprises increasing phosphorylation of Nato3 in the brain cells and culturing the brain cells until a progenitor dopaminergic neuronal cell marker or a dopaminergic neuronal cell marker is expressed in the cultured brain cells. Methods for treating Parkinson's disease (PD) in a subject comprises administering to the subject in need thereof, a composition comprising progenitor dopaminergic neuronal cells and/or dopaminergic neuronal cells expressing a Nato3 mutant polypeptide to the brain of the subject.
An isolated mutant Nato3 polypeptide, the polypeptide comprising at least one mutation in any one or more serine or threonine amino acid residues in the HLH domain defined by amino acids 99 to 158 of SEQ ID NO:
An isolated mutant Nato3 polypeptide, the polypeptide comprising at least one mutation in any one or more serine or threonine amino acid residues in the HLH domain defined by amino acids 99 to 158 of SEQ ID NO:
Dependencies are inferred from the claim text.