US 11,111,265 B2Granted

Method for preparing cholic acid compound

AssigneeChia Tai Tianqing Pharmaceutical Group Co., Ltd.

InventorsXiquan Zhang, Xingdong Cheng, Aiming Zhang, Chunguang Xia, Lang Chen, Ce Gao

Life of this patent

Estimating the term…

Loading patent…

Abstract

The present application relates to a method for preparing a cholic acid compound. Specifically, the method prepares a compound as shown in formula I, including subjecting a compound of formula 2 to an oxidization reaction to obtain a compound of formula 3; attaching a trimethylsilyl group to the compound of formula 3 to obtain a compound of formula 4; reacting the compound of formula 4 with acetaldehyde to obtain a compound of formula 5; subjecting the compound of formula 5 to a catalytic hydrogenation reaction to obtain a compound of formula 6; and converting a cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I.

Claims20

Dependent claims

A preparation method for a compound of formula I,

comprising the following steps:
a) subjecting a compound of formula 2 to an oxidization reaction in a solvent to obtain a compound of formula 3,
b) attaching a protecting group to the compound of formula 3 in a solvent to obtain a compound of formula 4,
c) reacting the compound of formula 4 with acetaldehyde in a solvent to obtain a compound of formula 5,
d) subjecting the compound of formula 5 to a reduction reaction in a solvent under a catalyst to obtain a compound of formula 6,
e) converting cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I,
wherein, said R1 and R2 are each independently selected from a silyl ether protecting group.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/759,134Filed 1 Nov 2018
Priority: CN 201711062367.62 Nov 2017
Published: US 2020/0347091 A15 Nov 2020
Granted: 7 Sep 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07J 9/005
Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g.…:…
C07J 41/0094
Not covered by C07J41/0005: containing nitrile radicals, including thiocyanide radicals
C07J 51/00
Normal steroids with unmodified cyclopentahydrophenanthrene skeleton not provided for in groups c07j1/00
C07J
Steroids

Family

US 2020/0347091 A1Pre-grant publication · published 5 Nov 2020
US 11,111,265 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

Building an agent or pulling many patents? Use the API or MCP server instead of scraping pages. Get an API key