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US 11,111,238 B2Granted
Coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer
AssigneesLead Discovery Center GmbH, Max Planck Gesellschaft zur Förderung der Wissenschften e.V., SOTIO a.s.
InventorsRaffaella Di Lucrezia, Tim Bergbrede, Peter Nussbaumer, Uwe Koch, Bert Klebl, Axel Choidas, Anke Unger, Nils-Göran Larsson, Maria Falkenberg-Gustafsson, Claes M. Gustafsson
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Abstract
The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.
Claims20
A compound of the general formula (I)
- wherein
- R is —C1-C4-alkyl;
- R1 is —H, or -methyl;
- M is CH or N;
- W is
- wherein
- R2 is C1-C4-alkyl, -halogen, —CN;
- X is -halogen, or —CN;
- n=0, 1, or 2;
- Y is —NR3R4 wherein
- R3 is —H, or —C1-C4-alkyl, and
- R4 is —C1-C4-alkyl or —C3-C6-cycloalkyl;
- or
- an unsubstituted or substituted pyridine residue;
- or
- an unsubstituted or substituted phenyl residue;
- or
- Y is —NR3R4 with N, R3 and R4 forming an unsubstituted or substituted 5- or 6-membered saturated heterocycle;
- or
- Y is —OR11, with R11 is —H or —C1-C4-alkyl;
- or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof.
18 more elements
Dependencies are inferred from the claim text.