Systems and methods to eliminate bubbles using ultrasonic energy

Abstract

A system to reduce surface bubbles from cell culture media using ultrasonic pulses is disclosed. The system includes a plurality of ultrasonic transducers, a photodetector, a camera, a control circuit, and a cell culture container that includes a cell culture media. The control circuit is communicatively coupled to the plurality of ultrasonic transducers, the temperature sensor, and the camera. The photodetector is used to determine a presence of a surface bubble on the cell culture media. The camera is used to determine a location of the surface bubble when the presence of the surface bubble is determined. The plurality of ultrasonic transducers is used to position an ultrasonic pulse at the location of the surface bubble and thereby reduce the presence of the surface bubble on the cell culture media when the location of the surface bubble is determined.

Dependencies are inferred from the claim text.