Systems and methods for optimization of plasma collection volumes

A system for collecting plasma comprising:

• a venipuncture needle for drawing whole blood from a donor;
• a blood separator for separating the whole blood into a plasma product and a second blood component comprising red blood cells, the blood separator having a plasma output port connected to a plasma line for sending the plasma product component to a plasma product collection container;
• a donor line fluidly connected to the venipuncture needle for introducing the whole blood from the donor to the separator and for returning concentrated red blood cells to the donor, flow through the donor line being controlled by a first pump;
• an anticoagulant line connected to an anticoagulant source, the anticoagulant line configured to introduce anticoagulant into the donor line;
• and
• a controller configured to control the operation of the blood component separation device and the first pump, the controller configured to calculate a target donor raw plasma volume (VRP) to be collected prior to an initial draw phase and/or a target plasma product volume (VPP) to be collected based, at least in part, on a weight, height and sex of the donor and a hematocrit (Hct) of the donor and the volume of anticoagulant to be added to the target donor raw plasma volume based on an anticoagulant ratio (ACR) and the hematocrit (Hct) of the donor, wherein the controller is further programmed to determine the target plasma product volume (VPP) based on the target donor raw plasma volume (VRP), the hematocrit (Hct) and an anticoagulant ratio (ACR) such that:
• VPP=VRP*K, wherein K=(ACR*(1-Hct/100)+1)/(ACR*(1-Hct/100)).