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US 11,110,206 B2Granted
Silk sericin-based hydrogel, methods and uses thereof
AssigneeUniversidade CatóLica Portuguesa
InventorsAna Leite De Almeida Monteiro De Oliveira, Sara Isabel Macedo Baptista Da Silva, Sandra Cristina Ferreira Borges, Paulo Jorge Pereira Alves
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Abstract
The present disclosure relates to a novel sericin-based hydrogel wherein the silk sericin is enzymatically cross-linked for an improved treatment of wound healing, ischemic diseases or cardiovascular diseases, namely chronic wound healing, in particular diabetic wound.
Claims18
A hydrogel comprising:
- at least 4% (w/v) of an enzymatically cross-linked silk sericin,
- wherein the silk sericin is enzymatically cross-linked by an enzyme complex selected from the group consisting of:
- horseradish peroxidase and hydrogen peroxide, laccase, transglutaminase, and mixtures thereof;
- wherein a cross-section of said hydrogel has pores with a diameter between 50-100 μm, and;
- wherein the hydrogel is suitable for medicinal applications, veterinary applications, cosmetic applications or as an in vitro model for cell culture studies.
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Dependencies are inferred from the claim text.