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US 11,110,186 B2Granted
Anionic chelate compounds
AssigneeGeneral Electric Company
InventorsBrian Christopher Bales, Michael James Rishel
Life of this patent
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Abstract
The invention provides compounds suitable for use as contrast agents in magnetic resonance imaging (MRI). The compounds of the present invention are manganese (II) complexes having advantageous properties as compared with similar known compounds.
Claims14
A compound of Formula I or a salt or solvate thereof:
- wherein:
- n is an integer of 1 to 4
- R1 is C1-3 alkyl or —(CH2)n+1—C(═O)—NR2R3;
- each X is —C(═O)—NR2R3 or —NH—C(═O)—R3;
- each R2 is hydrogen, C1-4 alkyl or an anionic substituent;
- each R3 is an anionic substituent optionally linked via a C1-4 alkylene;
- and,
- R4 is independently selected from the group comprising hydroxy, halo, amino, amido, C1-6 alkyl and C1-6 hydroxyalkyl and m is between 0-3, wherein each anionic substituent is independently selected from phosphate, phosphonate, hydroxycarboxylate, tetrazole, thiazolidindione, nitromethylsulfonylphenyl, 4-nitrothiophenol, nitromethylcarboxyphenyl, 2,4-dinitrophenol, or malonitrile.
5 more elements
Dependencies are inferred from the claim text.