Virus-like particle conjugates for diagnosis and treatment of tumors
AssigneesAura Biosciences, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsElisabet de los Pinos, John Todd Schiller, Rhonda C. Kines, John MacDougall
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Abstract
The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
Claims14
A tumor-targeting virus-like particle comprising papilloma virus capsid proteins and 50 to 1000 photosensitive molecules conjugated to the capsid proteins, wherein the photosensitive molecules comprise (a) a photosensitive molecule that becomes toxic or produces a toxic molecule upon activation by light and (b) a photosensitive molecule that does not become toxic or produce a toxic molecule upon activation by light.
A method comprising delivering to a subject a tumor-tropic virus-like particle comprising papilloma virus capsid proteins and 50 to 1000 photosensitive molecules conjugated to the capsid proteins, wherein the photosensitive molecules comprise (a) a photosensitive molecule that becomes toxic or produces a toxic molecule upon activation by light and (b) a photosensitive molecule that does not become toxic or produce a toxic molecule upon activation by light.
Dependencies are inferred from the claim text.