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US 11,110,178 B2Granted
Antibody adjuvant conjugates
AssigneesThe Board of Trustees of the Leland Standford Junior University, Bolt Biotherapeutics, Inc.
InventorsMichael Nathaniel Alonso, Edgar George Engleman, Shelley Erin Ackerman, Justin Kenkel, Arthur Lee, David Y. Jackson
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Abstract
The invention provides an immunoconjugate comprising an antibody construct which includes an antigen binding domain and an Fc domain, an adjuvant moiety, and a linker, wherein each adjuvant moiety is covalently bonded to the antibody via the linker. Methods for treating cancer with the immunoconjugates of the invention are also described.
Claims30
An immunoconjugate comprising
- (a) an antibody construct comprising (i) an antigen binding domain and (ii) an Fc domain,
- (b) an adjuvant moiety of formula:
- wherein each J independently is hydrogen, OR4, or R4, each R4 independently is hydrogen, or an alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl group comprising from 1 to 8 carbons, each U independently is CH or N wherein at least one U is N, each subscript t independently is an integer from 1 to 3, Q is optionally present and is an alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl group comprising from 1 to 8 carbons, and the dashed line (“”) represents the point of attachment of the adjuvant, and
- (c) a linker,
- wherein the adjuvant moiety is covalently bonded to the antibody construct via the linker.
2 more elements
Dependencies are inferred from the claim text.