US 11,110,159 B2 · Methods for inducing an immune response

Abstract

The present invention relates to methods for inducing an immune response, in particular methods for inducing an immune response against mycobacterial infections or disease comprising (i) at least one administration of a polypeptide Rv1196 related antigen and at least one administration of an adenovirus encoding a Rv1196 related antigen or (ii) at least one administration of a polypeptide Rv0125 related antigen and at least one administration of an adenovirus encoding a Rv0125 related antigen. Associated compositions, adenoviral constructs and polynucleotide sequences are also provided.

Claims9

Dependent claims

A method for inducing an immune response comprising a T cell response in a subject comprising:

administration of a chimpanzee adenovirus encoding a Rv1196 related antigen comprising SEQ ID NO:
1, followed by administration of a polypeptide Rv1196 related antigen to the subject, wherein the polypeptide Rv1196 related antigen is provided in a composition which also comprises an adjuvant.

Dependencies are inferred from the claim text.

Facts

Application

15/747,671Filed 25 Jul 2016

Priority

GB 151317627 Jul 2015

Published

US 2018/0250375 A16 Sep 2018

Granted

7 Sep 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification23 codes

A61K 39/04
Bacterial antigens: mycobacterium, e.g. Mycobacterium tuberculosis
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 35/761
Viruses; Subviral particles; Bacteriophages: adenovirus
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens

Methods for inducing an immune response

Life of this patent

Methods for inducing an immune response

Life of this patent

Abstract

Claims9