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AssigneePfizer Inc.
InventorsJoseph John Binder, Helen Kim Cho, Michael Robert Dermyer, Karin Ute Jooss, Brian Gregory Pierce, Joyce Tsi Tan, Van To Tsai, James Richard Merson
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The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.
A plasmid vector which comprises a multi-antigen construct encoding two different immunogenic polypeptides, wherein each of the immunogenic polypeptides is encoded by a coding nucleotide sequence on the multi-antigen construct, wherein the multi-antigen construct comprises a separator sequence between the two coding nucleotide sequences, wherein one of the two different immunogenic polypeptides is an immunogenic PSMA polypeptide and the other immunogenic polypeptide is an immunogenic PSA polypeptide, and wherein the immunogenic PSA polypeptide consists of an amino acid sequence selected from the group consisting of:
Dependencies are inferred from the claim text.