Silk fibroin materials and use thereof
AssigneesTrustees of Tufts College, Massachusetts Institute of Technology
InventorsDavid L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
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Abstract
The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
Claims16
A three-dimensional body comprising silk fibroin having interconnected pores, wherein the pores have an average diameter between 50 microns and 100 microns, and wherein total porosity of the three-dimensional body is at least 80%.
A three-dimensional silk fibroin body comprising interconnected pores having an average diameter between 50 microns and 100 microns, wherein the porosity is at least 80%, the silk fibroin body further comprising a biodegradable polymer selected from the group consisting of collagens, polylactic acid or its copolymers, polyglycolic acid or its copolymers, polyanhydrides, elastin, glycosaminoglycans, polysaccharides, and any combinations thereof.
Dependencies are inferred from the claim text.