Collagen hydrolysates as a beneficial prebiotic and their effect on joint inflammation and osteoarthritis
AssigneesRousselot B.V., University of Rochester
InventorsMichael Zuscik, Janne Prawitt, Eric Schott, Robert Mooney, Christopher Farnsworth
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Abstract
The invention generally relates to pharmaceuticals and/or nutraceuticals. More particularly, the invention provides compositions of collagen-based peptides and specific digestive tract microbes useful for supporting or promoting joint, skin and/or bone health, and methods of preparation and use thereof. The invention further provides for the use of compositions of collagen-based peptides as a prebiotic for modulating the gut microbiome.
Claims17
A method of administering a prebiotic to a subject comprising administering to the subject a prebiotic composition comprising hydrolyzed collagen peptides, wherein the hydrolyzed collagen peptides are type 1 hydrolyzed collagen peptides (hCol1) originating from bovine, or type 2 hydrolyzed collagen peptides (hCol2) originating from porcine, wherein the hCol1 have a mean molecular weight between about 1800 Da and about 3500 Da and the hCol2 have a mean molecular weight between about 1300 Da and about 3000 Da.
A method of preventing or treating joint inflammation in a subject comprising administering to the subject a composition comprising hydrolyzed collagen peptides, wherein the hydrolyzed collagen peptides are type 1 hydrolyzed collagen peptides (hCol1) originating from bovine, or type 2 hydrolyzed collagen peptides (hCol2) originating from porcine, wherein the hCol1 have a mean molecular weight between about 1800 Da and about 3500 Da and the hCol2 have a mean molecular weight between about 1300 Da and about 3000 Da.
A method for preventing or treating osteoarthritis in a subject, comprising administering to the subject a composition comprising hydrolyzed collagen peptides, wherein the hydrolyzed collagen peptides are type 2 hydrolyzed collagen peptides (hCol2) that originate from porcine collagen from cartilage, wherein the hCol2 have a mean molecular weight between about 1300 Da and about 3000 Da.
A method of administering a chondroprotective agent to a subject comprising administering to the subject a composition comprising hydrolyzed collagen peptides, wherein the hydrolyzed collagen peptides are type 2 hydrolyzed collagen peptides (hCol2) originating from porcine, wherein the hCol2 have a mean molecular weight between about 1300 Da and about 3000 Da.
Dependencies are inferred from the claim text.