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US 11,110,126 B2Granted
Method of expanding NK cell and composition for culturing
AssigneeKorea University Research and Business Foundation
InventorsKyung-Mi Lee, Jeongwon Sohn, Seon Ah Lim, Jang-Mi Lim
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Abstract
Provided are a method of ex-vivo culture of natural killer (NK) cells by treating the cells with a reactive oxygen species (ROS) inhibitor and/or a p53 protein inhibitor; and a composition comprising the cultured NK cells. By reducing the activity of ROS and p53 proteins during ex-vivo culture, NK cells may have achieved greater expansion efficiency without altering their anti-tumor cytotoxicity.
Claims6
A method of enhancing NK cell expansion, comprising:
- treating natural killer (NK) cells with a p53 inhibitor;
- or a reactive oxygen species (ROS) inhibitor and a p53 inhibitor, wherein the p53 inhibitor is one or more selected from the group consisting of 2-(2-imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide (pifithrin-α) and pifithrin-μ.
Dependencies are inferred from the claim text.