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US 11,110,124 B2Granted
Cell derived extracellular vesicles for the treatment of diseases
AssigneeRheinische Friedrich-Wilhelms-Universitaet Bonn
InventorsChristoph Coch, Juliane Dassler-Plenker, Gunther Hartmann
Life of this patent
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Abstract
The present invention pertains to extracellular vesicles (exosomes) that are produced by culturing tumor cells in the presence of various ligands or activators of innate immunity receptors and subsequently isolating and purifying the vesicles in the culture supernatant. The invention provides also pharmaceutical compositions comprising the inventive exosomes. The exosomes of the invention are provided as medicaments for example in the treatment of cancer diseases.
Claims11
A method for the production of extracellular vesicles, the method comprising the steps of
- (a) Culturing a tumor cell, an epithelial cell, or a fibroblast,
- (b) Bringing into contact the tumor cell, the epithelial cell, or the fibroblast with at least one ligand of an innate immunity receptor in an amount and time sufficient for the tumor cell, the epithelial cell, or the fibroblast to release extracellular vesicles with an anti-infective and/or anti-tumor activity and/or immune stimulatory activity,
- (c) Isolating and/or purifying the released extracellular vesicles.
Dependencies are inferred from the claim text.