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AssigneesTriumvira Immunologics USA, Inc., McMaster University
InventorsJonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi
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A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
A HER2 (Human Epidermal Growth Factor Receptor 2) T cell-antigen coupler (HER2-TAC) polypeptide, comprising the amino acid sequence set forth in SEQ ID NO:
An engineered T cell, comprising a recombinant expression vector comprising the nucleic acid sequence of SEQ ID NO:
A recombinant expression vector comprising:
Dependencies are inferred from the claim text.