Loading patent…
AssigneeAlps Pharmaceutical Ind. Co., Ltd.
InventorsNaoto Yamaguchi, Yui Sudaka, Mitsunori Ono
Estimating the term…
A water-soluble composition including an O-glycosyl flavonoid compound, L-arginine, a sugar alcohol, and ascorbic acid or an alkali salt of ascorbic acid. The O-glycosyl flavonoid compound is rutin, isoquercitrin, or hesperidin, and a molar ratio between the O-glycosyl flavonoid compound and the sugar alcohol is 1:4.0-12.0. Also provided is a method for making the above-described water-soluble composition by combining the O-glycosyl flavonoid compound, L-arginine, the sugar alcohol, and ascorbic acid or an alkali salt thereof to form a mixture, and heating it at 110° C.-140° C. to melt the mixture.
A water-soluble composition comprising an O-glycosyl flavonoid compound, L-arginine, a sugar alcohol, and an alkali salt of ascorbic acid, wherein the O-glycosyl flavonoid compound is selected from the group consisting of rutin, isoquercitrin, and hesperidin, the sugar alcohol is selected from the group consisting of maltitol, erythritol, xylitol, and sorbitol, the molar ratio between the O-glycosyl flavonoid compound and the L-arginine is 1:0.5-2.0 and the molar ratio between the glycosyl compound and the sugar alcohol is 1:4.0-12.0.
A method for producing a water-soluble O-glycosyl flavonoid composition, the method comprising combining an O-glycosyl flavonoid compound, L-arginine, a sugar alcohol, and an alkali salt of ascorbic acid to form a mixture, and heating the mixture at 110° C.-140° C. for a time sufficient to melt the mixture, wherein the O-glycosyl flavonoid compound, the L-arginine, the sugar alcohol, and the alkali salt of ascorbic acid are each in solid form;
Dependencies are inferred from the claim text.