Methods for treatment of cancer by targeting SIRT5

A compound that inhibits Sirt5 demalonylase or desuccinylase activity, having the formula:

• wherein:
• R1 is a carboxylate alkyl ester;
• R2 is S;
• X0, X1, X2, X3, X6, and X7 are each —CH2—;
• X4 is —NR5—, wherein R5 is H, methyl, ethyl, isopropyl, phenyl, or benzyl;
• X5 is —CH2— or —NR5—;
• R3 and R4 are independently selected from H, hydrocarbon (R), amino acid, dipeptide, tripeptide, oligopeptide, protein, nucleobase, nucleotide, dinucleotide, trinucleotide, oligonucleotide, monosaccharide, disaccharide, oligosaccharide, and protecting groups or a combination thereof or modified form thereof.