US 11,110,105 B2 · Compounds, composition and uses thereof for treating cancer

Abstract

The present invention relates to the fields of medicine and cancer treatment. The invention more specifically relates to new compounds which are typically for use as a medicament. In particular, the invention relates to the use of these new compounds for increasing the presentation, typically the production and presentation, of Pioneer Translation Products (PTPs)-derived antigens by cancer cells in a subject, and inducing or stimulating an immune response in the subject. The present disclosure also relates to uses of such compounds, in particular to prepare a pharmaceutical composition and/or to allow or improve the efficiency of a cancer therapy in a subject in need thereof. The invention also discloses methods for preventing or treating cancer, cancer metastasis and/or cancer recurrence in a subject. The present invention in addition provides kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.

Claims22

Dependent claims

A medicament comprising a compound of formula

wherein R1 and R2 are independently selected from the group consisting of Na, H, —CH3, —CH2—CH3, —CH2—CH═CH3, n-CH2—CH2—CH3, P(O)(O—CH2—CH3)2, P(O)(OH)2 or P(O)(ONa)2 and wherein R1, R2, R3, R4 and R5 are not H simultaneously, wherein R1 is not —CH3 when R2 is P(O)(ONa)2 or P(O)(OH)2 and each of R3, R4 and R5 is H, and wherein R1 is not —CH3 or H when R2 is —CH3 and each of R3, R4 and R5 is H;
and
wherein R3, R4 and R5 are independently selected from the group consisting of H, CH3, —CH2—CH3, —CH2—CH═CH3, and CnH2n+1 with n=3−10.

Dependencies are inferred from the claim text.

Facts

Application

16/604,599Filed 11 Apr 2018

Priority

EP 1730543812 Apr 2017

Published

US 2020/0297741 A124 Sep 2020

Granted

7 Sep 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 31/665
Phosphorus compounds: having oxygen as a ring hetero atom, e.g. fosfomycin
C07D 311/30
With aromatic rings attached in position 2 only: not hydrogenated in the hetero ring, e.g. flavones
A61K 31/352
Having six-membered rings with one oxygen as the only ring hetero atom: condensed with carbocyclic rings, e.g. methantheline
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…

Compounds, composition and uses thereof for treating cancer

Life of this patent

Compounds, composition and uses thereof for treating cancer

Life of this patent

Abstract

Claims22