Combination therapies for the treatment of alzheimer's disease and related disorders
AssigneeThe General Hospital Corporation
InventorDavid R. Elmaleh
Life of this patent
Estimating the term…
Abstract
The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits AB peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with Tau or alpha-synuclein; or regulates amyloid peptide washout.
Claims22
A method of treating or slowing the progression of a disease or condition in a human subject in need thereof comprising administering sublingually, intranasally, or to mucous membranes in the subject, a therapeutically effective amount of cromolyn or a salt thereof, wherein the disease or condition is Alzheimer's disease, dementia, an amyloidosis-associated condition, or a head injury.
A method of treating or slowing the progression of a disease or condition in a human subject in need thereof comprising co-administering ibuprofen and sublingually, intranasally, or to mucous membranes in the subject, cromolyn or a salt thereof, wherein the disease or condition is Alzheimer's disease, dementia, an amyloidosis-associated condition, or a head injury.
Dependencies are inferred from the claim text.