Small molecule inhibitors of bacterial efflux pumps and methods of using same
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsAbigail L. Reens, Amy L. Crooks, Corrella S. Detweiler
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Abstract
An empirical Screen for Anti-infectives using Fluorescence microscopy of IntracellulaR Enterobacteriaceae (SAFIRE) was developed. Using this methodology, a library of small molecules and identified antimicrobials that are cell permeable and non-host-toxic were screened. Inhibitors of bacterial efflux pumps were identified as being implicated in antibiotic resistance and are attractive therapeutic targets for antimicrobials.
Claims11
A pharmaceutical composition comprising an effective amount of an efflux pump modulator compound and a pharmaceutically acceptable carrier, wherein the efflux pump modulatory compound has one of the structure:
- (EPM30)
- (EPM35), or
- (EPM43).
A method of treating a bacterial pathogen in a subject, the method comprising administering to the subject a therapeutically effective amount of an efflux pump modulator (EPM) compound, wherein the EPM is
Dependencies are inferred from the claim text.