Apremilast pharmaceutical compositions

A topical pharmaceutical composition of apremilast, comprising:

• a. 1-5% w/w of apremilast or pharmaceutically acceptable salt thereof;
• b. a first pharmaceutically acceptable carrier at a concentration range of 5-30% w/w;
• and
• c. a pharmaceutically acceptable excipient;
• wherein the first pharmaceutically acceptable carrier is selected from the group consisting of dimethyl sulfoxide, glycerol, propylene glycol, petrolatum, water, and a mixture thereof,
• wherein the pH of the said composition is ranging from pH 3 to 8, and
• wherein the said topical composition has the ratio of apremilast to carrier in the range of 1:100 to 100:1.