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US 11,110,076 B2Granted
Methods of treating disorders associated with glycosylation defective proteins
AssigneeCase Western Reserve University
InventorsAlagramam N. Kumar, Suhasini Gopal Ramanujam
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Abstract
A method of treating a glycosylation-defective protein associated disease or disorder in a subject, the method includes administering to the subject a therapeutically effective amount of a Sarco/ER ATPase (SERCA) inhibitor.
Claims18
A method of treating a glycosylation-defective protein associated disease or disorder in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of a Sarco/ER ATPase (SERCA) inhibitor, wherein the SERCA inhibitor induces unconventional secretory pathway transport of aggregated glycosylation-defective protein from endoplasmic reticulum of cells of the subject.
A method of treating cystic fibrosis associated with a ΔF508CFTR mutation of human cystic fibrosis transmembrane conductance regulator (CFTR) protein in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of a Sarco/ER ATPase (SERCA) inhibitor.
Dependencies are inferred from the claim text.