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US 11,110,074 B2Granted
Methods of improving the pharmacokinetics of doxepin
AssigneeCurrax Pharmaceuticals LLC
InventorsCara Baron Casseday, Elizabeth Ludington, Michael Skinner, Susan E. Dubé, Roberta L. Rogowski, Philip Jochelson, Robert Mansbach
Life of this patent
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Abstract
Methods of improving the pharmacokinetics of doxepin in a patient.
Claims19
A method of treating insomnia, the method comprising:
- administering between about 0.5 mg and 7 mg doxepin to a patient in need thereof, wherein the doxepin is administered at least 3 hours after consuming a meal to provide faster onset of action.
A method of treating insomnia in a patient in need thereof, the method comprising:
- administering between about 0.5 mg and about 7 mg doxepin to the patient at least 3 hours after consuming a meal to provide faster onset of action, wherein administration of doxepin to a group of patients after a meal compared to administration of doxepin to a group of fasted patients provides:
- an increase in area under the curve (AUC) of doxepin;
- an increase in maximum plasma concentration (Cmax) of doxepin;
- or
- a delay in median time to reach maximum plasma concentration (Tmax) of doxepin.
2 more elements
Dependencies are inferred from the claim text.